This page tracks new and upcoming treatment options for multiple sclerosis (MS). What’s in development? What’s promising? What’s available soon? Current topics include ABX-002, BIIB061, ALKS 8700, CNM-Au8, Dapansutrile, IMU-838, EHP-101, ofatumumab, stem cells, NLRP, FMT, icariin, evobrutinib, and more. Jump to section: News, Research, Clinical Trials
Last updated: 4 years ago
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News
- Regulatory T cells could lead to new immunotherapies aimed at treating multiple sclerosis Sep 21, 2020
- Novartis data at ACTRIMS-ECTRIMS highlight the strength of leading multiple sclerosis (MS) portfolio with life-changing therapies for people across the MS spectrum Sep 8, 2020
- #MSVirtual2020 – Meeting Focus Is on Advances in MS Research, Diagnostics, and Technology Sep 4, 2020
- SomaCeuticals Acquires License for Treatment of Multiple Sclerosis Aug 24, 2020
- Key gene identified for improving multiple sclerosis treatment Aug 14, 2020
- “Reelin” In A New Treatment For Multiple Sclerosis – Depleting key protein could protect against conditions marked by chronic inflammation Aug 12, 2020
- Drug prevents multiple sclerosis relapses in phase 3 trial Aug 5, 2020
- Immunic’s multiple sclerosis med IMU-838 trounces placebo in phase 2 Aug 3, 2020
- Hookworm trial offers new hope to MS patients Jun 18, 2020
- Helius Medical Technologies, Inc. Announces FDA Has Granted the PoNS Device Breakthrough Device Designation for the Treatment of Gait Deficits Due to Symptoms of Multiple Sclerosis May 12, 2020
- 2020 Dystel Prize for MS Research Goes to Dr. Ian Duncan for Advances in Understanding Myelin Repair May 11, 2020
- VBL First-in-class MOSPD2 Antibodies Show Potential for Treatment of Multiple Sclerosis May 4, 2020
- Compound in fruit peels halts damage and spurs neuronal repair in multiple sclerosis – Ursolic acid, abundant in fruit peels and some herbs, both prevents and repairs neurons in animal models of MS Apr 6, 2020
- #ACTRIMS2020 – CNM-Au8 a Potential ‘Breakthrough’ in MS Therapy, Clene CMO Says Mar 16, 2020
- MedDay Reports Top-Line Data from Phase 3 Trial SPI2 for Treatment of Progressive Forms of Multiple Sclerosis: MD1003 fails to meet its primary and secondary endpoints Mar 10, 2020
- New multiple sclerosis treatment trial compares stem cell transplantation to best available drugs Jan 7, 2020
- Flashing lights may provide vital first test of multiple sclerosis drug success Dec 16, 2019
- Study shows the progression of multiple sclerosis can be slowed – without some of the health risks associated with current treatments Nov 25, 2019
- New Potential Multiple Sclerosis Treatment Being Tested In Canada Nov 25, 2019
- Liberation therapy: What we know about the controversial MS treatment 10 years later Nov 22, 2019
- Mallinckrodt Announces Data Publication on the Treatment Effectiveness of Acthar® Gel (Repository Corticotropin Injection) for Resolution of Multiple Sclerosis Relapse Nov 7, 2019
- New research to stop Multiple Sclerosis Oct 28, 2019
- Clene Nanomedicine Awarded Research Grant from the National Multiple Sclerosis Society to Support Clinical Development of its Lead Nanocatalytic Therapeutic, CNM-Au8 Oct 14, 2019
- University of Virginia team discovers surprise contributor to multiple sclerosis Oct 7, 2019
- Targeting certain rogue T cells prevents and reverses multiple sclerosis in mice Oct 4, 2019
- Diabetes drug offers hope of new treatment for multiple sclerosis: Trial using rats showed the drug metformin repaired nerve damage caused by the disease Oct 2, 2019
- Trigger for MS and Other Immune Diseases May Be T-cells in Early Activation State, Study Reports Sep 30, 2019
- Genomic map implicates broad immune cell involvement in multiple sclerosis Sep 26, 2019
- UB researchers discover clues to boost MS diagnosis, treatment Sep 25, 2019
- Myelin Repair, Clinical Trials, Gut Bacteria, and Exercise Headline at ECTRIMS2019, the World’s Largest MS Research Meeting Sep 23, 2019
- Researchers develop a promising new ‘Trojan horse’ treatment for multiple sclerosis Sep 19, 2019
- Author J.K. Rowling Donates $18.8 Million to Research Into the Treatment of Multiple Sclerosis Sep 15, 2019
- First results of new stem cell therapy trial announced Sep 12, 2019
- Mapi Pharma to Present Series of Recent Advancements for Treating Multiple Sclerosis (MS) at ECTRIMS 2019 Sep 4, 2019
- The Road to Better Multiple Sclerosis Therapy Aug 28, 2019
- After Her Years of Research, a Cambridge Scientist Could Be on the Verge of Curing Multiple Sclerosis Aug 25, 2019
- Four women now in remission from multiple sclerosis thanks to experimental treatment Aug 15, 2019
- Cyxone Announce Dosing of First Patient in First-In-Human Trial of T20K, in Development for the Treatment of Multiple Sclerosis (MS) Jul 12, 2019
- Emerald Health Pharmaceuticals Demonstrates Repair of Nerve Damage Related to Multiple Sclerosis: Preclinical data show remyelination with the clinical-stage drug product candidate, EHP-101 Jul 2, 2019
- Nanotechnology treatment shows promise against multiple sclerosis Jun 5, 2019
- Celgene Submits Application to EMA for Ozanimod for the Treatment of Relapsing-Remitting Multiple Sclerosis Mar 11, 2019
- How metabolites target brain-homing immune cells to treat multiple sclerosis Feb 28, 2019
- New compound offers superior therapeutic approach to treat MS Feb 21, 2019
Research
- Should I stop or should I go on? Disease modifying therapy after the first clinical episode of multiple sclerosis Sep 14, 2020
- Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis Sep 11, 2020
- How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process Sep 8, 2020
- Icariin ameliorates the progression of experimental autoimmune encephalomyelitis by down-regulating the major inflammatory signal pathways in a mouse relapse-remission model of multiple sclerosis Aug 29, 2020
- A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition Aug 29, 2020
- Longitudinal Serum Neurofilament Levels of Multiple Sclerosis Patients Before and After Treatment with First-Line Immunomodulatory Therapies Aug 28, 2020
- When a T cell engages a B cell: novel insights in multiple sclerosis Aug 24, 2020
- Ponesimod for the treatment of relapsing multiple sclerosis Aug 18, 2020
- Immunoregulatory effects and therapeutic potential of Vitamin D in multiple sclerosis Jul 15, 2020
- A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders Jul 14, 2020
- Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders, including MS Jul 14, 2020
- Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits Jun 9, 2020
- Inhibition of the NLRP3-inflammasome prevents cognitive deficits in mice via the alteration of astrocyte phenotypes: a novel therapeutic strategy for hippocampal impairment in multiple sclerosis May 15, 2020
- Ubiquitin biology in neurodegenerative disorders such as multiple sclerosis: from impairment to current and future promising therapeutic strategies May 11, 2020
- Zinc chelation and AMPK inhibition with 1H10 may have great therapeutic potential for the treatment of multiple sclerosis May 10, 2020
- Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis Apr 22, 2020
- Glycyrrhizic acid promotes neural repair by directly driving functional remyelination and could be a potential therapeutic candidate for multiple sclerosis (MS) Dec 6, 2019
- Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis Dec 2, 2019
- Fingolimod Increases Brain-Derived Neurotrophic Factor Level Secretion from Circulating T Cells of Patients with Multiple Sclerosis Nov 12, 2019
- The temporal and causal relationship between inflammation and neurodegeneration in multiple sclerosis Nov 4, 2019
- OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, could have clinical benefit for the treatment of multiple sclerosis in humans Nov 1, 2019
- Pharmacological Inhibitors of the NLRP3 Inflammasome Oct 25, 2019
- Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis Oct 24, 2019
- Intranasal delivery of SDF-1α preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone-induced mouse model of multiple sclerosis Oct 21, 2019
- The emerging role of galectins in remyelination and its potential for developing new approaches to treat multiple sclerosis Oct 18, 2019
- Review: Use of Autologous Hematopoietic Cell Transplant (AHCT) for Multiple Sclerosis Oct 17, 2019
- Therapeutic potential of aryl hydrocarbon receptor (AhR) in autoimmune diseases such as MS Oct 15, 2019
- Long term multiple sclerosis drug delivery using dendritic polyglycerol flower-like microspheres (DPGlyM): potential for use in treatment Oct 14, 2019
- Ceramide and sphingosine biosynthesis can be regulated by miRNA, which can be used as a therapeutic approach for multiple sclerosis (MS) Oct 11, 2019
- High mobility group box 1 (HMGB1) protein in multiple sclerosis (MS): Mechanisms and therapeutic potential Oct 10, 2019
- Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells Oct 3, 2019
- Disease modifying mitochondrial uncouplers, MP101, and a slow release ProDrug, MP201, in models of Multiple Sclerosis Oct 1, 2019
- Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations Sep 26, 2019
- Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders Sep 25, 2019
- Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis Sep 24, 2019
- Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model Sep 16, 2019
- CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis Sep 16, 2019
- Mesenchymal stromal cells attenuate multiple sclerosis via IDO-dependent increasing the suppressive proportion of CD5+ IL-10+ B cells Sep 15, 2019
- Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives Sep 12, 2019
- Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): study protocol for two phase I clinical trials Sep 9, 2019
- Impact of interferon β-1b, interferon β-1a and fingolimod therapies on serum interleukins-22, 32α and 34 concentrations in patients with relapsing-remitting multiple sclerosis Sep 6, 2019
- Early effective treatment may protect from cognitive decline in paediatric multiple sclerosis Sep 5, 2019
- Lysosomes as a therapeutic target in neurodegenerative diseases – including multiple sclerosis Sep 2, 2019
- Modulating REV-ERBα activity may be used to manipulate Th17 cells in multiple sclerosis Aug 27, 2019
- The Effect of Repetitive Transcranial Magnetic Stimulation on Spasticity in Patients with Multiple Sclerosis Aug 23, 2019
- Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances, and Limitations Aug 23, 2019
- Interleukin-6 (IL6) Disrupts Synaptic Plasticity and Impairs Tissue Damage Compensation in Multiple Sclerosis Aug 20, 2019
- Sema3A and miR-497-5p can be considered critical targets for further studies on future treatments of autoimmune diseases such as multiple sclerosis Jul 3, 2019
- Plasma cell and B cell-targeted treatments for use in advanced multiple sclerosis Jun 26, 2019
- MicroRNAs (miRNAs) as next generation targets in multiple sclerosis Jun 25, 2019
- Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis Jun 20, 2019
- A review for the neuroprotective effects of andrographolide in the central nervous system Jun 7, 2019
- The gut microbiota perspective for interventions in MS Jun 7, 2019
- P2X7 receptor: A potential therapeutic target for autoimmune diseases, including multiple sclerosis Jun 7, 2019
- A proof-of-concept application of a novel scoring approach for personalized medicine in multiple sclerosis May 30, 2019
- Plasma protein profiling reveals candidate biomarkers for multiple sclerosis treatment May 29, 2019
- Pharmacoeconomics of synthetic therapies for multiple sclerosis May 15, 2019
- Therapeutic effect of transplanted umbilical cord mesenchymal stem cells in a cynomolgus monkey model of multiple sclerosis Apr 15, 2019
- Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota Apr 12, 2019
- Stem Cell-Based Therapies for Multiple Sclerosis: Current Perspectives Mar 30, 2019
- Sulforaphane-enriched broccoli sprouts might be a potential nutraceutical with antineuroinflammatory and neuroprotective effects Mar 27, 2019
- Mesenchymal Stem Cell Therapies in Brain Disease Mar 25, 2019
- Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a Review of Current Literature and Future Directions for Transplant Haematologists and Oncologists Mar 4, 2019
- Integrative analysis of OIP5-AS1/HUR1 to discover new potential biomarkers and therapeutic targets in multiple sclerosis Feb 27, 2019
- Therapeutic effect of oligomeric proanthocyanidin in cuprizone-induced demyelination Feb 27, 2019
- Reduced disease severity following therapeutic treatment with angiotensin 1-7 in a mouse model of multiple sclerosis Feb 25, 2019
- Potential Therapeutic Features of Human Amniotic Mesenchymal Stem Cells in Multiple Sclerosis: Immunomodulation, Inflammation Suppression, Angiogenesis Promotion, Oxidative Stress Inhibition, Neurogenesis Induction, MMPs Regulation, and Remyelination Stimulation Feb 20, 2019
- Cross-reactivity between myelin oligodendrocyte glycoprotein and human endogenous retrovirus W protein: nanotechnological evidence for the potential trigger of multiple sclerosis Feb 18, 2019
- The protective effects of β-caryophyllene on LPS-induced primary microglia M1/M2 imbalance: A mechanistic evaluation Feb 15, 2019
- The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment Feb 12, 2019
- Frontal brain activity and cognitive processing speed in multiple sclerosis: An exploration of EEG neurofeedback training Feb 11, 2019
- The Role of B Cells and Antibodies in Multiple Sclerosis, Neuromyelitis Optica, and Related Disorders Feb 8, 2019
- B-Cell Therapies in Multiple Sclerosis Feb 1, 2019
- KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions Dec 1, 2018
- The role of B cells in multiple sclerosis: Current and future therapies Oct 21, 2018
- Economic Evaluation of Stem Cell Therapies in Neurological Diseases: A Systematic Review Aug 30, 2018
- Membrane attack complex (MAC) inhibition might be a relevant treatment for chronic neuroinflammatory diseases May 3, 2018
Clinical Trials
- A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS) Sep 15, 2020
- Study of Evobrutinib in Participants With Relapsing Multiple Sclerosis (RMS) Aug 31, 2020
- Dendritic Cells Therapy Combined With Immunomodulatory Treatment in Multiple Sclerosis (TolDecCOMBINEM) Aug 28, 2020
- Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton’s Tyrosine Kinase (BTK) Inhibitor SAR442168 Aug 26, 2020
- Fecal Microbial Transplantation (FMT) for Relapsing Multiple Sclerosis Patients (MS-FMT) Aug 20, 2020
- Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS) Aug 18, 2020
- A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis Aug 5, 2020
- Study to Evaluate Oral BIIB061 Added to Interferon-beta1 (IFN-β1) in Relapsing Multiple Sclerosis (RMS) Jul 7, 2020
- Efficacy and Safety of IMU-838 in Relapsing Remitting Multiple Sclerosis (EMPhASIS) May 5, 2020
- A Pilot Study of Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis Mar 23, 2020
- A Study of ALKS 8700 in Adults With Relapsing Remitting Multiple Sclerosis (MS) EVOLVE-MS-1 Mar 13, 2020
- Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis (REPAIR-MS) Jan 18, 2020
- An Open Label Extension Study of Ublituximab in Subjects With Relapsing Multiple Sclerosis Oct 18, 2019
- Efficacy of Early Harvest Olive Oil in Cognition of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis Oct 9, 2019
- Comparative Study of the Efficacy and Safety of BCD-132 With Teriflunomide and Placebo in Multiple Sclerosis Aug 14, 2019
- Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis Jul 19, 2019
- Cladribine Tablets: Collaborative Study to Evaluate Impact On Central Nervous System Biomarkers in Multiple Sclerosis May 24, 2019
- Long-Term Outcomes and Durability of Effect Following Treatment With Cladribine Tablets for Multiple Sclerosis (MS) May 23, 2019
- Thermal Cures in the Treatment of Multiple Sclerosis Apr 16, 2019
- tDCS to Lower Neuropathic Pain and Fatigue in People With Multiple Sclerosis Mar 11, 2019
- Pharmacodynamic and Immunologic Effects of Vitamin D Supplementation in Patients With Multiple Sclerosis and Healthy Control Mar 5, 2019